One pill. Once a day.
All-day effectiveness.

Now your patients can get the same effective treatment for urinary incontinence (UI) due to urethral sphincter hypotonus that you’ve come to trust from PROIN® in a convenient, once-a-day dose with PROIN ER™ (phenylpropanolamine hydrochloride extended-release tablets).

Thanks to the controlled release mechanism in our patented extended-release technology, PROIN ER™ maintains steady absorption throughout the day. Plus, there’s no washout period when transitioning from PROIN to PROIN ER. Factor in its delicious liver flavoring, and it all adds up to improved compliance and happier dogs and families.

Easy to prescribe weight-band dosing

18 mg
38 mg
74 mg
145 mg
10-20 lbs.
21-40 lbs.
41-80 lbs.
81-125 lbs.
99%

of owners, when asked on Day 28, assessed their dog as “improved” or “stayed the same.”1

82.2%

of doses voluntarily consumed when given without or with a small amount of food.1

PROIN ER by the numbers

PROIN ER is an effective, easy-to-use treatment of UI due to urethral sphincter hypotonus in spayed, female dogs.

1Pegasus Laboratories, Inc. (2019). Freedom of Information (FOI) Summary for PROIN ER™ (phenylpropanolamine hydrochloride extended-release tablets) Dogs: US, (NADA 141-517). Center for Veterinary Medicine (CVM).

The PROIN ER advantage

1x per day

One extended-release tablet per day can be conveniently given with food.

Accurate dosing

Available in four weight-based strengths for accurate dosage of virtually any sized dog weighing 10 pounds or more. See prescribing information for details.

Enticing flavor

Delicious tablets improve compliance and make treatment easy.

Steady absorption

Patented extended-release technology provides controlled release that ensures steady absorption.

FDA-approved

The only once-a-day, FDA-approved medication for the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Convenient packaging

30 ct. & 90 ct. bottles are conveniently sized for storage and dosing.

1x per day

One extended-release tablet per day can be conveniently given with food.

Accurate dosing

Available in four weight-based strengths for accurate dosage of virtually any sized dog weighing 10 pounds or more. See prescribing information for details.

Enticing flavor

Delicious tablets improve compliance and make treatment easy.

Steady absorption

Patented extended-release technology provides controlled release that ensures steady absorption.

FDA-approved

The only once-a-day, FDA-approved medication for the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Convenient packaging

30 ct. & 90 ct. bottles are conveniently sized for storage and dosing.

What is urinary incontinence?

Urinary incontinence (UI) occurs when dogs involuntarily lose urine due to lack of bladder control. It typically starts 2-4 years after a female dog is spayed, but can begin sooner or later. Medium to large breed dogs are commonly affected, but small breed dogs may also develop urinary incontinence.1,2

Signs of urinary incontinence (UI):

• Dripping, leaking urine  • Wet spots where dog sleeps  • Excessive licking of genitals  • Red, irritated skin in the genital area  • Inappropriate urination indoors

1Holt PE. Urinary incontinence in the bitch due to sphincter mechanism incompetence: prevalence in referred dogs and retrospective analysis of sixty cases. Journal of Small Animal Practice 1985;26:181–190.

2Holt PE, Thrusfield MV. Association in bitches between breed, size, neutering and docking, and acquired urinary incontinence due to incompetence of the urethral sphincter mechanism. Vet Rec 1993;133:177–180.

Additional resources

See below for more information regarding PROIN ER and canine urinary incontinence (UI) including prescribing information, articles and videos, and a helpful checklist for dog owners when talking to their veterinarian.

Prescribing information

Prescribing information for PROIN ER for the treatment of UI due to urethral sphincter hypotonus.

Articles and videos

Learn more about UI, its causes and the effectiveness of PROIN ER.

Discussion guide

A convenient resource for dog owners to help guide the conversation about UI.

Veterinary resources

Valuable information and insights from veterinary experts about canine UI and PROIN ER.

Is PROIN ER right for your dog?

Since urinary incontinence may be new to you, here’s a helpful list of questions your veterinarian may ask to help in the diagnosis (along with performing tests like urine culture, blood tests, abdominal imaging, or ultrasound). Answering these questions before the first appointment could be the first step in managing your dog’s leaking issues.

Is PROIN ER right for your dog?

Since urinary incontinence may be new to you, here’s a helpful list of questions your veterinarian may ask to help in the diagnosis (along with performing tests like urine culture, blood tests, abdominal imaging, or ultrasound). Answering these questions before the first appointment could be the first step in managing your dog’s leaking issues.